Meaning Of Asymptomatic Hyperuricemia
Definition uric acid a product of purine metabolism is degraded in most mammals by the hepatic enzyme urate oxidase uricase to more highly soluble allantoin which is freely excreted in the urine.
Meaning of asymptomatic hyperuricemia. The definition etiology and management of asymptomatic hyperuricemia will be reviewed here. See clinical manifestations and diagnosis of gout and treatment of gout flares and pharmacologic urate lowering therapy and treatment of tophi in patients with. Despite the fact that uric acid was first identified approximately 2 centuries ago certain pathophysiologic aspects of hyperuricemia are still not clearly understood.
The four phases of gout include asymptomatic hyperuricemia acute gouty arthritis. Asymptomatic hyperuricemia until larger placebo controlled studies are completed. Although hyperuricemia isn t a disease if uric acid levels remain high over.
Hyperuricemia is an abnormally high level of uric acid in the blood in the ph conditions of body fluid uric acid exists largely as urate the ion form. Only about one third of people with hyperuricemia experience symptoms. Debate persists regarding the benefit of treating all cases of asymptomatic.
Hyperuricemia is defined as a plasma uric acid concentration 6 8 mg dl. Patients with asymptomatic hyperuricemia had significantly higher average number of risk factors lower hdl cholesterol and higher creatinine and triglycerides levels lower ejection fraction ef. Serum uric acid concentrations greater than 6 mg dl for females 7 mg dl for men and 5 5 mg dl for youth under 18 years old are defined as hyperuricemia.
For years hyperuricemia has been identified with or thought to be the same as gout but uric acid has. The definition and management of asymptomatic hyperuricemia has been an area of controversy for many decades. This is known as asymptomatic hyperuricemia.
The mean value of serum acidum uricum sua was 345 5 100 3 µmol l where 115 22 8 patients had asymptomatic hyperuricemia. Patients receiving no urate lowering. Gout is a condition characterized by the deposition of monosodium urate crystals in the joints or soft tissue.